Preclinical animal trials of osteointegrated tubular bone implants were conducted in 2023 as part of the breakthrough project of UIREC “Reconstructive Surgery and Express Implantation”. The trials were supported by the Ministry of Health of the Russian Federation as part of the state assignment for research and development.
The trials were conducted by the National Medical Research Center of Traumatology and Orthopedics named after Academician G. A. Ilizarov together with Ural Federal University and the Sensor Enterprise. The project “Reconstructive Surgery and Express Implantation” is aimed at restoring hand functions in case of partial or complete loss of fingers using original surgical technology and implantable structures. It is based on the possibilities offered by personalized medicine. In other words, it is done what is necessary for a particular person in their specific situation. This personalization defines the niche occupied by scientists and doctors of the Urals in the Russian market of reconstructive surgery and implantation.
“In 2023, a comparative study of osteointegration of screw-in implants and Press-Fit implants was performed, the installation of which is accompanied by the formation of bone chips, which contributes to the rapid formation of bone matrix and shortening of the implant engraftment period. The design development and manufacturing of implants from various biocompatible materials were carried out at Sensor Enterprise. The team of scientists of Ural Federal University did a large-scale research of physical and mechanical properties of implants manufactured using different techniques. An innovative solution of bone compression loading was used in the osseointegration studies. The method of compression loading and the device for its application are protected by patents of the Russian Federation for invention and utility model,” said Viktor Kuznetsov, Doctor of Technical Sciences, Professor, Head of the Laboratory of Scientific Research of Biomechanics and Engineering at the Ilizarov Center.
The development of an innovative automated stand for the study of multiplanar deformations of the bone biomechanical system during osteosynthesis is now coming to an end. Application of the stand will allow to determine the necessary set of characteristics of the bone biomechanical system with external fixation devices based on experimental measurement of axial, transverse and rotational stiffness under simulation of various types of impacts. The research results have been published in highly rated journals indexed in the Scopus database.
Under the auspices of the project, the Youth Laboratory of Kurgan State University “Promising Materials for Industry and Biomedicine” and its key partners obtained small batches of ultrafine-grained TiNbZr alloys using post-processing technology. This has allowed for uniformity in the modulus of elasticity and microhardness throughout the workpiece, resulting in significantly improved operational characteristics and implant quality. The registration process for corresponding medical devices is planned for the future.
It should be noted that the “Reconstructive Surgery and Express Implantation” project from the Kurgan region is included among the breakthrough projects of the Ural Research and Educational Center. The UIREC program for 2024 aims to refine high readiness level technologies for market entry between 2025 and 2030.
Source: kgsu.ru